Abstract: Powdery mildew caused by Oidium mangiferae, is the most important disease of mango. It is reported from 35 countries in the world and reported to cause up to 90% loss in India. Besides inflorescence infection, it causes different types of symptoms on leaves and fruits. Based on epidemiological studies and control measures conducted for the last 15 years at CISH, Lucknow (Uttar Pradesh, India), a disease cycle and an integrated disease management practice is proposed. Disease can easily be controlled by adopting suitable cultural practices and timely application of spray schedule. As the disease is weather-sensitive, need-based control measures are suggested based on the prevailing environmental conditions.