Abstract: Boron deficiency in papaya causes deformation of apical meristem, distortion of young leaves, dwarfing of plants, fruit deformities and uneven fruit ripening that severely reduces the yield and quality. Hence, an experiment on effects of foliar application of boron on yield and quality of papaya with a commercially important variety Red lady was conducted at fifteen locations of Andhra Pradesh where the boron deficiency is wide spread due to tropical climate and high soil pH. Foliar application of 0.03 % borax at every 60 days interval from planting to harvest recorded significant increase in the leaf boron content from 18.44 mg kg^-1 to 26.62 mg kg^-1. Borax application recorded 29 % more number of fruits per plant, 37 % higher yields (65.28 kg plant^-1) and reduced deformed fruits (13.58 %) compared to control (21.34 %). The study clearly indicated that, the regular supply of boron through foliar application in tropical climate is vital for realizing higher yields in papaya.